— Through Week 7 —
| Player | Pac-12 Team | NFL Team | Solo Tackles | Total Tackles |
|---|---|---|---|---|
| Blake Martinez | Stanford | Giants | 45 | 73 |
| Eric Kendricks | UCLA | Vikings | 48 | 66 |
| Shaq Thompson | Washington | Panthers | 31 | 60 |
| Budda Baker | Washington | Cardinals | 48 | 59 |
| Jordan Poyer | OSU | Bills | 42 | 58 |
| Justin Reid | Stanford | Texans | 34 | 44 |
| Krys Barnes | UCLA | Packers | 25 | 43 |
| Jayon Brown | UCLA | Titans | 25 | 43 |
| Myles Jack | UCLA | Jaguars | 26 | 41 |
| Troy Hill | Oregon | Rams | 30 | 41 |
| Taylor Rapp | Washington | Rams | 28 | 40 |
| Isaiah Oliver | Colorado | Falcons | 25 | 38 |
| Cory Littleton | Washington | Raiders | 23 | 35 |
| Bobby Okereke | Stanford | Colts | 25 | 33 |
| Terrance Mitchell | Oregon | Browns | 25 | 32 |
| Malcolm Smith | USC | Browns | 25 | 32 |
| Eric Rowe | Utah | Dolphins | 23 | 31 |
| Cameron Jordan | Cal | Saints | 17 | 29 |
| DeForest Buckner | Oregon | Colts | 17 | 28 |
| Leonard Williams | USC | Giants | 14 | 25 |
| Kenny Young | UCLA | Rams | 13 | 25 |
| Marcus Williams | Utah | Saints | 18 | 25 |
| Ugo Amadi | Oregon | Seahawks | 24 | 25 |
| Byron Murphy Jr. | Washington | Cardinals | 19 | 24 |
| Jaylon Johnson | Utah | Bears | 18 | 23 |
| Danny Shelton | Washington | Lions | 7 | 22 |
| Brennan Scarlett | Stanford | Texans | 14 | 22 |
| Steven Nelson | OSU | Steelers | 17 | 21 |
| Uchenna Nwosu | USC | Chargers | 12 | 20 |
| Everson Griffin | USC | Cowboys | 10 | 20 |
| Marcus Peters | Washington | Ravens | 17 | 19 |
| Cody Barton | Utah | Seahawks | 12 | 19 |
| Lawrence Guy | ASU | Patriots | 10 | 18 |
| Arik Armstead | Oregon | 49ers | 9 | 17 |
| Nickell Robey-Coleman | USC | Eagles | 13 | 16 |
| Kevin King | Washington | Packers | 12 | 16 |
| Tyson Alualu | Cal | Steelers | 9 | 16 |
| James Vaughters | Stanford | Bears | 13 | 15 |
| Devante Downs | Cal | Giants | 9 | 14 |
| Jimmy Smith | Colorado | Ravens | 12 | 14 |
| Trent Murphy | Stanford | Bills | 9 | 12 |
| Tedric Thompson | Colorado | Chiefs | 10 | 12 |
| Darnay Holmes | UCLA | Giants | 8 | 12 |
| Antwaun Woods | USC | Cowboys | 2 | 11 |
| Henry Anderson | Stanford | Jets | 5 | 11 |
| Michael Thomas | Stanford | Texans | 6 | 11 |
| Ahkello Witherspoon | Colorado | 49ers | 7 | 10 |
| Porter Gustin | USC | Browns | 5 | 10 |
| Devon Kennard | USC | Cardinals | 8 | 10 |
| Julian Blackmon | Utah | Colts | 9 | 10 |
| Jacob Tuioti-Mariner | UCLA | Falcons | 10 | 10 |
| Sidney Jones | Washington | Jaguars | 9 | 10 |
| Justin Hollins | Oregon | Rams | 6 | 10 |
| Jaylinn Hawkins | Cal | Falcons | 6 | 9 |
| John Penisini | Utah | Lions | 2 | 9 |
| Greg Gaines | Washington | Rams | 4 | 9 |
| Takkarist McKinley | UCLA | Falcons | 5 | 8 |
| Terrell Burgess | Utah | Rams | 7 | 8 |
| Ezekiel Turner | Washington | Cardinals | 1 | 7 |
| Kenny Clarke | UCLA | Packers | 4 | 7 |
| Demetrius Flannigan-Fowles | Arizona | 49ers | 5 | 6 |
| Ashtyn Davis | Cal | Jets | 3 | 6 |
| Fabian Moreau | UCLA | Washington | 4 | 6 |
| Dion Jordan | Oregon | 49ers | 4 | 5 |
| Kyle Fitts | Utah | Cardinals | 3 | 5 |
| Leki Fotu | Utah | Cardinals | 2 | 5 |
| Joe Walker | Oregon | 49ers | 4 | 4 |
| Harrison Phillips | Stanford | Bills | 3 | 4 |
| Davion Taylor | Colorado | Eagles | 3 | 4 |
| Will Parks | Arizona | Eagles | 3 | 4 |
| Desmond Trufant | Washington | Lions | 4 | 4 |
| Garrett Bolles | Utah | Broncos | 1 | 2 |
| Matt Dickerson | UCLA | Titans | 0 | 2 |
| Nate Orchard | Utah | Washington | 0 | 2 |
| Francis Bernard | Utah | Cowboys | 1 | 1 |
| Jordan Miller | Washington | Falcons | 1 | 1 |
| Javelin Guidry | Utah | Jets | 0 | 1 |
| Jordan Richards | Stanford | Ravens | 0 | 1 |
| Ken Crawley | Colorado | Saints | 1 | 1 |
| Ben Burr-Kirvin | Washington | Seahawks | 1 | 1 |
| Jared Norris | Utah | Washington | 1 | 1 |